Curriculum Vitae
Research Articles:
SAXS Analysis of the Bifunctional Antibiotic Resistance Enzyme AAC(6′)-Ie/APH(2”)-Ia Reveals a Rigid Solution Structure. (2012) Caldwell, S.J., and Berghuis, A. M. Antimicrobial Agents and Chemotherapy 56(4): 1899-1906.
Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2″)-Ia. (2016) Caldwell S.J., Huang Y., Berghuis A.M. Structure 24(6): 935–945.
I’ve described the findings in this article here.
Crystal Structures:
5BYL: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of AAC(6′)-Ie/APH(2”)-Ia) in complex with GMPPCP and Magnesium
5IQA: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of AAC(6′)-Ie/APH(2”)-Ia) in complex with GMPPNP and Magnesium
5IQB: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of AAC(6′)-Ie/APH(2”)-Ia) in complex with GMPPNP, Magnesium, and Kanamycin A
5IQC: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of AAC(6′)-Ie/APH(2”)-Ia) in complex with GMPPNP, Magnesium, and Gentamicin C1
5IQD: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of AAC(6′)-Ie/APH(2”)-Ia) in complex with GMPPNP, Magnesium, and Ribostamycin
5IQE: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of AAC(6′)-Ie/APH(2”)-Ia) in complex with GMPPNP, Magnesium, and Neomycin B
5IQF: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of APH(6′)-Ie/APH(2”)-Ia) in complex with GDP and Magnesium
5IQG: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of AAC(6′)-Ie/APH(2”)-Ia) in complex with GDP, Magnesium, and Gentamicin C1
5IQH: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of AAC(6′)-Ie/APH(2”)-Ia) S214A mutant in complex with GMPPNP and Magnesium
5IQI: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of AAC(6′)-Ie/APH(2”)-Ia) Y237F mutant in complex with GMPPNP and Magnesium
Helical Translations 