Shane Caldwell

Curriculum Vitae

Shane Caldwell Academic CV

Research Articles:

SAXS Analysis of the Bifunctional Antibiotic Resistance Enzyme AAC(6′)-Ie/APH(2”)-Ia Reveals a Rigid Solution Structure. (2012) Caldwell, S.J., and Berghuis, A. M. Antimicrobial Agents and Chemotherapy 56(4): 1899-1906.

Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2″)-Ia.  (2016) Caldwell S.J., Huang Y., Berghuis A.M. Structure 24(6): 935–945.

I’ve described the findings in this article here.

Crystal Structures:

5BYL: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of AAC(6′)-Ie/APH(2”)-Ia) in complex with GMPPCP and Magnesium

5IQA: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of AAC(6′)-Ie/APH(2”)-Ia) in complex with GMPPNP and Magnesium

5IQB: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of AAC(6′)-Ie/APH(2”)-Ia) in complex with GMPPNP, Magnesium, and Kanamycin A

5IQC: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of AAC(6′)-Ie/APH(2”)-Ia) in complex with GMPPNP, Magnesium, and Gentamicin C1

5IQD: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of AAC(6′)-Ie/APH(2”)-Ia) in complex with GMPPNP, Magnesium, and Ribostamycin

5IQE: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of AAC(6′)-Ie/APH(2”)-Ia) in complex with GMPPNP, Magnesium, and Neomycin B

5IQF: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of APH(6′)-Ie/APH(2”)-Ia) in complex with GDP and Magnesium

5IQG: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of AAC(6′)-Ie/APH(2”)-Ia) in complex with GDP, Magnesium, and Gentamicin C1

5IQH: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of AAC(6′)-Ie/APH(2”)-Ia) S214A mutant in complex with GMPPNP and Magnesium

5IQI: Aminoglycoside Phosphotransferase (2”)-Ia (CTD of AAC(6′)-Ie/APH(2”)-Ia) Y237F mutant in complex with GMPPNP and Magnesium

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